DESIGN OF FAST DISSOLVING ORAL FILMS OF DOMPERIDONE USING SOLVENT CASTING TECHNIQUE

Nil Conflict of Interest: This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3. A novel fast release oral film drug delivery system for the treatment of emesis in pediatrics and geriatric patients was developed for immediate oral delivery of Domperidone which is an excellent antiemetic drug. Different grades of polyox were used for film formation like N10, N80, N and N Support Center Support Center. Spectra showed presence of drug peak at same energy of enthalpy as that of pure QT. Fast dissolving oral Films are the novel dosage forms that disintegrate and dissolve within the oral cavity within a minute, without needing water or chewing. National Center for Biotechnology Information , U.

Thus, it can be concluded that by adopting a systematic formulation approaches, an optimum point can be reached in the shortest time with minimum effort. Spectra showed presence of drug peak at same energy of enthalpy as that of pure QT. Support Center Support Center. Glycerin and propylene glycol showed more sticky film which was unable to detach from surface. Poly ethylene glycol showed good film forming property with good flexibility. Stability study was carried out for 3 months in final optimized formulation. Experimental trials were performed at all 9 possible combinations with 5 replication batches. In this design 2 factors were evaluated, each at 3 levels.

Thus, developed film can be useful for curing the emergency condition like schizophrenia which gives rapid relief within short time. Glycerin and propylene glycol showed more sticky film which was unable to detach from surface.

Formulation development and optimization of polyox based quick dissolving film of quetiapine

After 3 months film was again evaluated for all parameters. The results of central composite design revealed that the entire factor significantly influences the dependent variable. Concentration of polymer and plasticizers were optimized by central composite design.

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Other parameters remain unaltered after 3 months of storage. Domperidone films were prepared by solvent casting technique using two water soluble polymers, Pullulan and Sodium carboxy methyl cellulose in different concentration. Author information Copyright and License information Disclaimer.

Authors are thankful to Dow chemicals for providing samples of Polyox. Authors acknowledge the Institute of Pharmacy, Nirma university and Saraswati institute of pharmaceutical sciences, Dhanap, Gandhinagar for providing the research facilities. For validation of optimum formulation, check point R14 was prepared and evaluated for all the response.

Quetiapine QT is used to treat schizophrenia attack and bipolar disorder having half-life of 6 hours. Some predictable changes were observed in film property like decrease ssolvent disintegration time and more softness of film due to higher amount of moisture. Experimental trials were performed at all 9 possible combinations with 5 replication batches. Film was prepared by solvent casting method.

Footnotes If of Support: Please review our privacy policy. Mendenhall W, Sincich T. Dellen Publishing Co; Check point batch was compared for predicted value with observed value. The prepared films were evaluated for their thickness uniformity, folding endurance, content uniformity, surface pH, In-vitro disintegration time and In-vitro drug release. A novel approach to drug delivery, Drug Development Technology.

Formulation development and optimization of polyox based quick dissolving film of quetiapine

Fast dissolving solveht Films are the novel dosage forms that disintegrate and dissolve within the oral cavity within a minute, without needing water or chewing. QT was received as gifted by Torrent Pharmaceuticals Pvt. Film is optimized for concentration of polymer and plasticizer using CCD design. Nil Conflict of Interest: Polyox N was selected for further optimization of film property due to its excellent film forming nature with optimum viscosity for rapid dissolving film.

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Infrared casitng revealed no interaction between Domperidone and polymers. Archive Journal of Psychiatry.

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The ultimate goal of any drug delivery system is the successful delivery of the drug to the body; however, patient compliance must not be overlooked. Conclusion The results of central composite design revealed that the entire factor significantly influences the dependent variable.

Stability study was carried out for 3 months in final optimized formulation. Ankit Chaudhary1 and A. Observed value was found close to the predicted value, which indicated good correlation of results.

Sunita ChaudharyB. FTIR spectra indicated that no interaction between drug and excipients.

fasst From the results it was observed that disintegration time of all the batches ranges between sec, tensile strength between 0. Methods for evaluating the puncture and shear properties of pharmaceutical polymeric films. A high and low dose double blind comparison with placebo. QT is rapidly absorbed and well tolerated drug.